For 35 years, G&H has continuously provided consulting engineering services to the Pharmaceutical Industry and Chemical Companies. including assessments, planning, code analysis. designing. and engineering problem solving solutions for the design and construction of renovation and new construction projects. In excess Of 125 projects have been completed. with a mechanical/electrical construction value Of over $250 million. In addition
to the commissioning and validation prtxess. many of the projects involve compliance with U.S. Federal Standards. such as AAALCA. USFDA and U.S. Pharmacopoeia Standards, including the implementation of GMP and CGMP practices.
Our work for these organizations has included the design of: laboratories. pharmaceutical manufacturing and packaging space in accordance With cGMP: cleanrooms: process improvements: domestic water. sewerage, steam. gas. compressed air piping, purified water. and other utilities; plumbing and piping; fire protection: security and fire alarm provisions: process controls; HVAC including: chemical fume hoods: biosafety cabinets; variable airvolume boxes; digital control systems; and HEPA filtration: and electrical upgrades.
“Gillan & Hartmann. Inc. has taken a complex design project involving completely gutting and renovating chemistry and biology laboratories and coordinating construction documents in just one year. In comparison. a project scope of this magnitude would normally run well over two years to achieve this degree of success. Extremely tight time constraints, large demands and an abundance of faith were placed in the hands of the design staff. (We) had to have this design in place and advertised for award within a short timeframe to avoid losing the funds. Gillan & Hartmann, Inc. completed design and construction documents on time and With
a level of success exceeding our expectations”
— Public Works Directorate
— Anthony C. Campano, Acting Director
— Gary C. Pacito, Architect
Cephalon, Inc.
West Goshen, PA
Cephalon is a leading biotechnology company conducting research into treatment of
neuro-degenerative diseases. With several products in clinical trials, the company was
poised for significant growth. To accommodate that growth, Cephalon sought to
double its current space to sq ft. The plan called for expansion and renovation
Of existing research facilities including chemistry, biology, toxicology. microbiology. and
analytical labs. Renovations included fume hood replacement. new air handlers and
exhaust systems. new lab services. and new and modified casework.
Gillan & Hartmann. Inc. was responsible for the design and specification of complete
utility systems (HVAC plumbing, fire protection and electrical) for a new 11,000 square
foot “Link” building and the renovation Of 45.cm square feet Of adjacent building
space. The Link building connected two buildings encompassing a library and cafeteria
and “linked- the owners existing facility and the adjacent building The adjacent
building space was completely renovated and utility services installed to serve solid
and Liquid Processing, Analytical Chemistry. Stability Chamtrrs and Administration
services. The design included a 7S KW emergency generator, a 130.ton air-cooled
chiller. new air handling units (Chilled water and direct expansion type). dust collection
system. vacuum pump, air and the installation Of laboratory gas systems.
GlaxoSmithKline
King of Prussia, PA
G&H has performed multiple engineering assignments for smithKline at its administrative. pharmaceutical laboratories. and manufacturing facilities. Some representative assignments include the following.
Design of New Infill Building: G&H participated in the development of the programming of the new 24,om sq. ft„
4 story Infill Building 29B. The facility was designed to provide new offices, warehouse space, environmental
rooms. GMP storage. and manufacturing space. included the review Of existing utility service. development Of mechanical and electrical system conceptual design, preparation of schematic diagrams. and input to the project cost estimate and schedule.
Building 29 GMP Area: Provided utility services (compressed air, DI water. vacuum cleaning, hot water, electrical power distribution), and HVAC system upgrade for 16,mo sq. ft. of GMP space. The upgrade included the of the existing CFM supply air handling unit to provide HEPA filtration. Responsibilities included the design and specification Of a Dl water loop, new 10 horsepower vacuum cleaning system. and the extension of compressed air, hot water. and electrical distribution services to the third floor production area. The renovation project supvx)r-ted the relocation of manufacturing equipment (fluid bed dryers, Accela Cota, granulators, tablet presses, etc.)
Renovation of Building 21 : G&H prepared the mechanical. electrical. and plumbing design to renovate 28 rooms on the first and third floors and four departments (Pharm Tech. Molecular Immunology. Combinatorial Screening Enzymology) of Building 21. The project included architectural modifications and revisions to existing mechanical. electrical. and plumbing systems to meet departmental needs.
U.S. Army Research Engineering and Development Center
Natick. MA
G&H was responsible for the architectural, plumbing, and mechanical design
components of the restoration and upgrade of laboratory facilities at the US, Armys
Natick Research, Development. and Engineering Center. The project stemmed from
the need to provide pollutant prevention and control measures in the laboratories to
systematically eliminate mercury discharges or emissions.
Phase I of the design work focused on Building 4. a 3-story. sq ft building which contained various biotechnoloo, chemical testing, fermentation, polymer, food biochemistry. and material testing laboratories: cleanrooms. offices. and conference rooms. The revitalization design called for approximately 66 Rrcent of the building to
be renovated and the remainder of the building to be kept in operation during the
renovation process.
Due to the age Of Building 4, it was determined that many components were in need Of
repair or upgrade to comply with current codes. Renovation of Building 4 involved replacement of all laboratories. offices, and conference rooms including ceilings, lighting. lab benches, ductwork. Sinks. including mechanical and plumbing systems necessary to upgrade the facility to meet all applicable OSHA
codes, The design team overcame tight budget and scheduling constraints in order to have the design in place and advertised for award within a short timeframe to avoid losing the federal funding. Of six bids received by the Government for construction of the facility, fiwr were within 2 percent of the G&H estimate.
“Gillan & Hartmann. Inc. (G&H) received an unsolicited letter of commendation from the U.S. Army for its work to revitalize laboratories at the Natick facility. The letter Cited G&H’S … •outstanding performance in designing the project. Through diligent efforts, highly skilled and professional leadership. the laboratory design is a huge success … Thank you for the pride you have taken with our project as it obviously shows.”
IBAH Pharmaceutics
Fort Washington, PA
G&H was engaged by Health sciences construction Group. Inc. (HSC) to prepare the mechanical, electrical, plumbing and fire protection engineering design for the fit-out Of 25.000 sq ft Of laboratory and Offices space for IBAH Pharmaceutics. a contract pharmaceutical manufacturer. The utility service equipment was carefully selected to facilitate the installation of laboratory equipment over a 2-year period while minimizing first cost and
maximizing operational control. The initial phase included an HPLC laboratory (2.100 sq ft gas chromatograph lab and dissolution lab sq ft). Ancillary laboratory spaces include sample preparation. sample receiving chemical storage, glasswash. and glass storage.
The firm also prepared the mechanical and electrical engineering design for the fit-out of a 32.0cx) sq ft space in a sq ft building to be leased by IBAH Pharmaceutics. The fit-out includes 12.0CN) sq ft of office space, sq ft of warehouse. and sq ft for labeling and packaging.
Flexibility of design to accommodate changing manufacturing needs was a critical element in the design of the space. The fit-out included providing all necessary utility services for a “Kalish une- and blister packaging equipment. Local HEPA filtration prevents cross-contamination in the primary packaging area.
Sanofi Winthrop, Inc.
Malvern. PA
AS prime professional. the firm was responsible for the renovation of approximately 60,000 sq. ft. of space for this
pharmaceutical manufacturer. Included was the modification of architectural amenities and HVAC systems for the
vivarium. laboratory. manufacturing area. and office space, Responsibilities included the utilization of equipment
and rooms contained in over 17,000 sq. ft. of manufacturing space for both solid and liquid products.
Renovations were also made to the Pilot plant and the addition of a new warehouse (7.000 sq. ft.) area to meet
current Good Manufacturing Practice requirements, Mechanical, electrical. and plumbing services were provided to the warehouse space which contained sampling,’dispensary, labeling. packaging. finished product storage (under quarantine) and returned good areas.
The scope of work required the utilization and specification of downflow sampling booths, chemical fume hoods. bio-safety cabinets and downdraft Stations. Work included the extension of compressed air and laboratory gas systems. modifications to the Chilled water and hot water heating systems. installation of an emergency generator. addition of boiler blowdown neutralization system, piping system for USP purified grade water, and a
modified and new fire protection system. campus security was enhanced through the installation of additional cameras and provision of card access to secure points of entry, Telephone/data and security employed “Level 5” wiring technology.
United States Department of Agriculture
Under terms of an Indefinite Deliverynndefinite Quantity (ID/IQ) Contract with the United States Department of Agriculture (USDA), G&H served as prime professional for substantial and significant renovations to: Utility source Master Planning; HVAC DCX control, Electrical and Plumbing Systems:
Energy conservation Engineering to serve critical Laboratory Testinnuality control Laboratories and Administrative support space. G&H design work required phasing Of the construction work to minimize interruptions. and temporary provisions to maintain continuous operation Of the USDA laboratories.
The various projects required conceptual planning. assessment. and cost definition for all mechanical. electrical systems serving RSL.2 laboratories, tannery modernization. irradiation spaces. pasteurization laboratories and instrument expansion and renovations. projects were successfully completed at the following locations.
State College. PA – pasture System & Watershed Management Research unit
Wyndmoor, PA Eastern Regional Research center (ERRC)
Located on the Penn State University State College Campus. the Research Unit supports environmentally and economically sustainable farming in the north eastern U.S. by improving agrckcosystem management. The Wyndmoor ERRC conducts fundamental, applied and developmental research on a broad spectrum of agricultural commodities.
United Chemical Technologies, Inc.
Bristol. PA
Gillan & Hartmann. Inc. was contracted for a five-phase project to reconstruct the United Chemical Technologies
Plant in Bristol. PA after a devastating fire destroyed a of the saline and silicone coatings plant. The first
phase of the work consisted of an assessment of building and utility systems followed by the design to support
the Construction Of four new laboratory modules. consisting Of three 50 liter laboratories and one 72 liter
laboratory. one 50 liter laboratory, adjacent to the high-bay area Will be fitted-out and finished to support the
plants distillation process for saline and Silicone products. The other three modules will be constructed as shell
space with utility services provided to the boundary of the shell space. The area of construction is about 6,8W sq.
ft.
AS part of the assessment, a G&H multi-diSCiplinary team conducted a field investigation and review of the
program and process requirements. Mechanical. electrical, plumbing and fire protection components were evaluated for physical condition and reuse to meet program requirements. G&H reviewed the building structure, classification, and BOCA code requirements to meet the program criteria and then generated a preliminary estimate of the total developed cost to implement the program.
The design of the new laboratory modules involved a review of program and process requirements; a revjew of Site utility documents for location. Size. and capacity to meet the program requirements; design of an efficient process layout in full compliance with all applicable regulations evaluation Of the feasibility Of including telephone, computer, and mechanical maintenance building in the program; a review Of the requirements to
provide storm drainage improvements north of the new reactor laboratory shell modules: review of the potential for temporary containment and pumped storage in the Drum Storage Area; develop a sketch concept for additional office space: review possible locations for a new process boiler: assess the capacity and condition of the existing cooling tower for reuse: define and confirm environmental testing (soil. water. air. etc.) to meet
regulatory requirements.
Additional Representative Projects:
Canon Research Laboratory
Cephalon, Inc.
colorcon corporation
E.I. dupont de Nemours and company
Fredrick National Cancer Center
I BAH Pharmaceutical
Immune Response
Johnson Matthey Pharmaceutical
McNeil consumer products company
Merck & Company
Pfizer Inc. Animal Health Group
Renal Testing Laboratory
Rohm and Haas
Rhone-Poulenc Rorer
Rohrer Pharmaceutical
Sanofi-synthelatx)
Schering-Plough corporation
Sermatech
SmithKline Beecham
Sterling Drug, Inc.
Sun Co., Adamantec
Sun Oil company
Total Renal Care
university science center (EISicon. Fraunhoffer Laboratories)
Wyeth Company
